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The second type is Non-REM (NREM) sleep, which is characterized by a regular occurrence of local and global slow cortical oscillations, visible at the level of the EEG as slow waves, neurons in the cortex and thalamus are bistable

Moreover, NO has been shown to induce the synthesis of NO per se 58 , indicating that the superfluous levels of NO in PD might lead to a vicious loop of NO production