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Angiotensin IV is a derivative of the potent vasoconstrictor angiotensin II and has been shown to enhance the acquisition, consolidation, and recall of learning and memory in animal models when administered centrally or peripherally

RAMPs change calcitonin receptor pharmacology from calcitonin-preferring to amylin-preferring by affecting receptor specificity and affinity

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These include pathogen-derived proteases such as Leishmania GP63 or malaria falcipains, or the localized reactive oxidative stress (ROS) characteristic of bacterial inflammatory niches (OLeary et al., 2023