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Isolated populations of slow-growing, label-retaining colon cancer and breast cancer cells had enhanced survival when exposed to a third-generation platinum derivative, oxaliplatin, compared to non-labelled cells [38]

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Commonly used measures (e.g., nerve conduction velocity, IENFD, and circulating inflammatory markers) each carry known variability and interpretive constraints, and emerging tools such as quantitative MR neuroimaging or minimally invasive sampling techniques have not yet been consistently integrated with pharmacokinetics, target engagement, and functional outcomes into a unified evidentiary chain (Winter et al., 2002