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This 16-amino acid fragment was first isolated during lipolysis research in the 1990s as scientists worked to identify the specific part of the GH molecule thats responsible for its fat-mobilising effects

Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification

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