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Acknowledgements The authors appreciate and thank the efforts of the Center for the Development of Clinical Researches of the Educational and Therapeutic Research Complex of Birjand University of medical science

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Mechanistic studies clarify that its reparative effects on diabetic wounds likely occur by inhibiting ferroptosis in vascular endothelial cells and fibroblasts, thereby improving cellular functions [78, 80]

219 Immunogenicity Exogenous nucleic acids can be recognized as exogenous signals by pattern recognition receptors in the immune system, triggering immune responses that compromise the structural integrity and stability of the nucleic acids