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Markers 34 (1), 5459

and enhances cell proliferation and lumen formation capabilities while inhibiting ROS levels and the expression of IL-6, IL-10, and TNF-, thereby attenuating apoptosis and protecting endothelial cells against IRI and inflammation (Yang et al., 2017)

Approaches such as chelation with targeted agents[81], combination therapies[82], polyphenolic plant compounds[83], and supplementation with essential trace elements like Se[84] may effectively reduce metal toxicity by exerting antioxidant and anti-inflammatory actions and facilitating the elimination of metals

During the 48-week treatment, IP-10 declined significantly from baseline to 48 weeks (0W, 12W, 24w, 48w median: 671.3 vs 431.3 vs 287.3 vs 269.5 pg/mL, p 1000 pg/mL was an independent predictor of complete virological response at 48 weeks (OR=5.26, 95% CI:1.27-21.71, p =0.022)