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It's strongly encouraged that you use this with care if you're taking any medicines, particularly over the counter medications

10.1001/jama.2020.9482 12 ChongJ.SoufanO.LiC.CarausI.LiS.BourqueG.et al (2018)

Mice exposed to chronic unpredictable mild stress (CUMS) for 6 weeks showed increased hypothalamic corticotropin-releasing hormone concentrations, elevated corticosterone levels and increased blood ammonia, which corresponded with anxiety-like behaviors, demonstrating HPA axis involvement in anxiety pathogenesis (Jia et al., 2024)