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( d ) Measurement of the distance traveled during the Open Field test (n Ctrl = 8 mice, n CORT = 15 mice, n GDF11 = 8 mice, n CORT-GDF11 = 16 mice

Chronic fatigue is often linked to nutrient deficiencies, mitochondrial dysfunction, or adrenal stress

No ethical permission was required from the Danish Animal Experiments Inspectorate because the animals were euthanized without undergoing experimental procedures

Successively the scenario was enriched by several molecular players that belong to redox-sensitive factors such as the Bcl-2 family (Hockenbery et al., 1993