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A.), 317333 (Elsevier, 2014)

Some patients experience mild warmth or slight soreness at the injection site, which resolves within a day

Signs of B12 deficiency, such as fatigue, weakness, numbness or tingling in the hands and feet, difficulty walking, memory loss, and mood changes, should not be overlooked

The combination creates a dual mechanism: naltrexone reduces food reward and craving intensity, while bupropion enhances the brain's satiety signals and provides mild stimulant-like appetite suppression