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Current EPA Guidelines Require Updated Uncertainty Factors The guidelines on risk assessment of neurotoxic agents (EPA 1998) clearly indicate that an uncertainty factor of ten should be applied when attempting to extrapolate a lowest-observed adverse-effect-level (LOAEL) to establish an REL, as is the case for studies of mercury vapor toxicity the threshold cannot be determined from available studies

A press release put out by the FDA in September 2020 specifically warns against the potential danger of mercury fillings in certain high-risk populations

p = 0.99) (Figure 5B)

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