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Below is a concise graphical representation summarizing this timeline: Gradual onset of testosterone benefits over time libido and sexual function improve within weeks, followed by gains in energy, muscle strength, and bone density across several months to two years (based on data from AUA 2024 and Mayo Clinic 2025)

Mitochondrial-Nuclear Communication: Under conditions of metabolic stress or exercise, MOTS-c translocates to the nucleus, where it regulates the expression of nuclear genes associated with stress adaptation and homeostasis