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Notably, senescent renal TECs may induce fibroblast activation and proliferation by releasing Sonic hedgehog protein, contributing to the progression of DKD (13)

Figure 1 Culturing in Ringer Solution at Low Hematocrit Increases the Baseline Levels of PS Exposure and Hemolysis in Erythrocytes To test the influence of specific culture conditions on baseline levels of eryptosis, and in the absence of any drug, nave erythrocytes were incubated in either Ringer solution (at 0.4 or 4% hematocrit) or in cRPMI at 4% hematocrit ( Figures 2A, B )

Several studies reported the critical role of zinc in oxidative stress-related kidney diseases