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Evaluation of the color change Standardized photographs were taken before the treatment, immediately after the treatment, and during the 6 th month follow-up, by a trained clinical photographer who is blinded to the study

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The detoxification of ROS is a multi-chain reaction, hence the upregulation of anyone enzyme is inadequate for organized and systematic detoxification and requires coordination with multiple enzymes for effective detoxification ( The core clock regulates the genes of redox hemostasis and instructs the cell to respond to oxidative damage