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In contrast, APAP-CYS was capable to induce only a mild impairment in HK-2 cells and APAP did not induce any significant changes in treated cells

METALLURGY C07ORGANIC CHEMISTRY C07CACYCLIC OR CARBOCYCLIC COMPOUNDS C07C227/00Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton C07C227/14Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof C07C227/18Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g