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(2006) have presented a newer model for the catalytic reaction in which Glu146 functions as a general base, accepting a proton from zinc-bound water and shuttling the proton to the leaving group facilitating breakdown of the tetrahedral intermediate

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Results NRTP significantly impaired ovarian function At present, no studies have investigated the impact of NRTP itself on ovaries, making it impossible to target and protect against NRTP-induced ovarian damage and decreased fertility before cancer diagnosis and cancer therapy in females