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phenomapping through unsupervised machine learning applied to high-dimensional EHR and clinical data to identify actionable subphenotypes within heterogeneous conditions [e.g., heart failure with preserved ejection fraction (HFpEF)] and differentiate likely responders from non-responders

This system generates positive reinforcement signals primarily through dopaminergic transmission within the mesolimbic circuit, mediated by dynamic interactions between the ventral tegmental area (VTA) and the nucleus accumbens (NAc).(Rice and Cragg, 2004

The dynamin-related protein (Drp-1) and its mitochondrial adaptor fission protein 1 (Fis-1) are the main responsible for mitochondrial fission, a process positively related to mitochondrial fragmentation and apoptosis (Frank et al., 2001

Pemmaraju N , Kantarjian H, O'Brien S, Verstovsek S, Jabbour E, Quintas-Cardama A, Garcia-Manero G, Borthakur G, Ravandi F, Shan J, Cortes J