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Managing GI side effects with either compound Regardless of which peptide a researcher chooses, GI management strategies remain similar

The most commonly researched combination is BPC-157 + TB-500, which pairs the VEGF/angiogenesis and gut-lining signalling of BPC-157 with the actin-binding cell-migration mechanism of TB-500 in a single vial

Lancet Oncol 16(6):619629 Demetri GD et al (2013) Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial

Second, PPI use increases the abundance of producing bile salt hydrolase (BSH) bacteria, such as Lactobacillus and Clostridium