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As was shown by Liu et al

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

By contrast, the antiphosphaturic effects of rhGH-treatment in children with inherited renal hypophosphatemia, i.e., X-linked hypophosphatemic rickets, were only transient, indicating the importance of other phosphaturic hormones, i.e., fibroblast growth factor 23, in this particular disease [50]

IGF-1 signalling has been linked to neurotrophic and neuroprotective processes , and IGF-1 LR3 provides a consistent model for exploring these effects