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Gut microbial communities have been observed to show differences between patients and healthy individuals

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Results showed that the Dex group had lower levels of serum urea nitrogen (BUN), creatinine (Cr), and neutrophil gelatinase-associated lipocalin (NGAL) at certain postoperative time points, higher intraoperative urine output, and a significantly reduced incidence of AKI, indicating that this drug can improve renal function and reduce the risk of kidney injury (175)

Another study further demonstrated that the FAD/NAD(P)H-binding site of FSP1 is evolutionarily conserved among NADH quinone reductases, and targeting this region enabled the development of viFSP1, a species-independent inhibitor that interacts with the NAD(P)H-binding pocket of FSP1 121