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Mood changes should be monitored clinically, not treated as a lab-only issue

Even though it was believed that most of the immune cells and other soluble molecules cannot pass between the CNS and other organs because of BBB and it protects the CNS from inflammation caused due to pathogens access to the host, it is known that the CNS has to be regularly checked for its proper functioning to ensure the absence of any injury or damage because of some pathogen [34, 58]

Expression of leucocyte adhesion molecules at the human blood-brain barrier (BBB)

For example, flavoring compounds and humectants used in vaping products, although generally recognized as safe for oral consumption, can cause adverse effects when inhaled, especially following heated aerosolization and subsequent degradation/oxidation