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In addition, while methods have been developed using either underivatized or derivatized sample preparation techniques [4], this method was developed without derivatization in order to simplify and speed up sample preparation

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Preterm pigs showed deficient body growth and altered growth trajectories for SI, colon, liver, spleen and brain compared with term pigs, together with immature intestinal digestive enzymes (e.g., reduced peptidase activities in the first weeks, reduced maltase/lactase activity at 19 days)

Viendo las dos modalidades del procedimiento en conjunto, la modalidad donde se utiliza un diluyente soluble en agua, presenta la ventaja de ser un procedimiento acuoso sin exposicin a solventes, mientras que en la modalidad del diluyente no soluble en alcohol, permite que la densidad de la composicin farmacutica sea mayor permitiendo el llenado en cpsula, por ejemplo una capsula de tamao 00 elongado (capacidad de 1.02 mililitros)