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was the first to report deceased circulating levels of HDL cholesterol and Apolipoprotein A-I (ApoA-I), the major protein component in HDL, in a combined cohort of patients with CVID (n=18) and X-linked agammaglobulinemia (XLA, n=6), compared to healthy controls ( While it is known that HDL can sequester lipopolysaccharide (LPS), and thereby prevent LPS-induced cellular activation through TLR4 ( Figure 2A )

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