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Bioremediation Journal, 23 (4), 259276

Jang, Y., Kwon, I., Song, W., Cosio-Lima, L

AMPK also promotes, albeit indirectly, PGC 1 deacetylation and activation, which is mediated by the NAD-dependent protein deacetylase sirtuin-1 (SIRT1) whose activation is a direct consequence of the increase in NAD + :NADH ratio (Canto and Auwerx, 2009)