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360 TGF- Crosstalk with PI3K, NF-B, HIF-1, MAPK, Wnt In addition to its interaction with BMPR2 signal transduction, TGF- can also interact with other signaling pathways (PI3K, NF-B, HIF-1, MAPK, and Wnt) to contribute to the EndMT, proliferation, and inflammation of PAECs, as well as promoting the proliferation of PASMCs and enhancing ECM remodeling of PAFs and RVFs (Fig