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The two medications work through entirely different mechanisms phentermine through central stimulant pathways, GLP-1s through appetite and metabolic signaling which is precisely why combining them can restart progress when either alone has stalled

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These include: Men with prostate cancer/had prostate cancer Those who have or ever had a heart disease, stroke, kidney problem, diabetes, liver problem, prostate problem, breast cancer, or prostate cancer Individuals with a history of blood clots Men with severe sleep apnea Taking TRT (testosterone replacement therapy) may worsen their condition