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Although this enzyme is very important in this process, other enzymes such as CYP3A4/5 are also involved (see the diagram)

Furthermore, the credibility of the findings should be regarding the possibility that the final endpoint of these concepts (cytoprotection organoprotection [41,42,43,44,45,46,47,48,49], reestablished body homeostasis [59,60,61]), response as such as claimed by both Robert and Selye [41,59], could ever be realized by the pharmacologic agent