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Patients and caregivers should also receive timely and up-to-date education about immunotherapies, their mechanism of action, and the clinical profile of possible irAEs prior to initiating therapy and throughout treatment and survivorship

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These pharmacokinetic challenges necessitate the development of innovative delivery systems such as nanoparticles, liposomes, and solid lipid carriers to enhance their stability, absorption, and targeted delivery of flavonoids (Billowria et al., 2024

Recurring episodes of anemia (megaloblastic) and an abnormal yellow coloration of the skin (jaundice) are also common