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It can trigger skin eruptions, sometimes in up to 1 in 5 (20%) treated patients

One study looked at people with lupus who took vitamin C and vitamin E supplements

Tumours were induced, and upon presentation of clinical symptoms of tumour burden, animals were randomized and treated with 150 mg kg 1 5FU three times per week, with 250 mg kg 1 metformin or vehicle control delivered concurrently (Fig