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Among previously suggested pathways are lipotoxicity arising from ectopic accumulation of fat in tissues other than adipose, such as liver and muscle (Mantzaris et al., 2011

Endocannabinoid-mediated control of synaptic transmission

doi: 10.1126/scitranslmed.abf8396 13 FukudaKStrausSEHickieISharpeMCDobbinsJGKomaroffA

30 The altered NP cell phenotype can maintain the catabolic environment during disc degeneration 31 and has shown to be responsible for the drop in local pH mediated by, among others, acidsensing ion channels (ASICs) 32 that in turn causes IVD cell loss and ECM breakdown