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The loss of astrocytes reduces the density of oligodendrocytes, initiates demyelination, and promotes myelin abnormalities (e.g., decompaction) in the white matter of developing and adolescent mice (7 days to ~1.5-months-old

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To dissect the biochemical derangements imposed by chronic hyperglycaemia, a three-dimensional, tissue-engineered wound model has been engineered that faithfully recapitulates the accumulation of AGEs and the attendant impairment of fibroblast proliferation, angiogenic signaling, and extracellular-matrix turnover that underlie the stalled diabetic repair program (129)