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[,] In animals, splenectomy attenuates concanavalin A (ConA)-induced hepatic fibrosis in mice by decreasing serum levels of TNF superfamily 14 (TNFSF14, or LIGHT), which can promote fibrosis through direct binding to TNFRSF3 (lymphotoxin receptor, LTR), but not TNFRSF14 (herpesvirus entry mediator, HVEM) on hepatic macrophages to increase JNK-mediated TGF-1 expression

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Modulation of inflammatory processes by regulating cytokine activity and reducing excessive tissue fibrosis

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