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Furthermore, studies on LRRK2 deficient mice showed no significant differences in animal behavior compared to the control using the open field test (Hinkle et al., 2012

Secondary diagnosis use: a confirmed condition exists, and generalized weakness represents a documented impairment that affects function and drives the treatment plan

Although ACSL4 is consistently upregulated in OA cartilage and linked to ferroptosis progression, its inhibition must be balanced to avoid disrupting normal PUFA metabolism required for membrane integrity and repair ( Altogether, these examples underscore that despite encouraging experimental results, ferroptosis-targeted drugs face multiple translational bottlenecks, including systemic toxicity, insufficient targeting, metabolic compensation, and biological heterogeneity

doi: 10.1016/j.biopha.2022.112834 111