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In a humanised antibody, only the complementarity determining regions (CDRs) which are responsible for antigen binding and specificity are animal derived and have an amino acid sequence corresponding to the animal antibody, and substantially all of the remaining portions of the molecule (except, in some cases, small portions of the framework regions within the variable region) are human derived and correspond in amino acid sequence to a human antibody

J Physiol Pharmacol 60(Suppl 7):93100 Singh N, Singh P, Shrivastva S, Mishra SK, Lakshmi V, Sharma R, Palit G (2012) Gastroprotective effect of anti-cancer compound rohitukine: possible role of gastrin antagonism and H(+) K (+)-ATPase inhibition

(India), was dissolved in distilled water to a final concentration of 2.5 mg/ml and administered by oral gavage in a dose of 20 mg/kg/day

This study was conducted in compliance with local legislation and institutional requirements