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Recently, nanomaterials possessing enzyme-like activities, termed nanozymes , have attracted considerable interest due to their advantages over their natural counterparts

In an assessment of leukocyte mitochondrial complex I activity in BD during depressive episodes after lithium treatment, a significant decline in depressive symptoms and manic episodes was observed throughout the treatment, with no statistical differences detected between male and female patients

However, several antioxidant defense systems (e.g., the SLC7A11-GSH-GPX4 system, Nrf2 signaling, and FSP1-CoQ10 system) can counteract cellular oxidative stress, thus blocking ferroptosis 31

Abnormalities in cholinergic receptors, particularly 7nAChRs, have been linked to neurodevelopmental disorders such as ASD [44]