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Effects of recombinant human insulin-like growth factor-I (IGF-I) therapy on the growth hormone-IGF system of a patient with partial IGF-I gene deletion

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Results HIV-1 JR-CSF infected microglia integrate into neural organoids and transfer viral particles to astrocytes, not neurons As a model to study the impact of HIV on the CNS and the role of metabolic reprogramming due to infection, we generated regionalized neural organoids with a forebrain identity, hereafter called neural organoids (NO) and co-cultured with HIV-1 JR-CSF infected microglia (HIV-MNO) or mock infected microglia (mock-MNO) (Fig