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Treatment with the Nrf2 inhibitor ML385 attenuated Dex's inhibitory effect on ferroptosis, further confirming that Nrf2 activation is a critical mechanism underlying Dex's protective effects [218]

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We explain the lack of reductase activity of ROXY9 in the HED and the Cys-SG assays by an unfavourable scaffold site as indicated by the redox titrations

Studies have demonstrated that in a neonatal rat model of hyperoxic lung injury, morphological changes such as mitochondrial shrinkage, membrane rupture, and a significant reduction in cilia can be observed in ATII cells (Yang et al