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The urine-GPX4-to-creatinine ratio (UGCR) was calculated

Concurrently, the inflammatory microenvironment further deteriorates the overall spermatogenic microenvironment by inhibiting the steroidogenic function of Leydig cells (e.g., TNF- inhibits the activity of key testosterone synthesis enzymes) and weakening the nutritional and physical support provided by Sertoli cells to germ cells (52)