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Studies show that inhibiting nicotinamide Nmethyltransferase (NNMT) enhances metabolic health by reducing adipose tissue accumulation, improving insulin sensitivity, and promoting better energy utilization

Oxidative medicine and cellular longevity, 2012(1), 324832

It is useful in the treatment of neuritis, polyneuritis, neuralgia, neuropathies, sciatica, facial paralysis, anemia, etc

The study found that NNMT inhibitors "reduced intracellular 1-MNA, increased intracellular NAD+ and S-(5-adenosyl)-L-methionine (SAM), and suppressed lipogenesis." This metabolic improvement occurs within days of starting treatment, before any weight loss becomes measurable