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doi:10.1016/j.tins.2020.12.002

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In the latter scenario, the lactic acidosis-based interception mechanism would allow more glycolytic intermediates to be diverted to biomass building, which, as our current work unravels, also includes metabolizing G6P towards the PPP for nucleotides synthesis (R5P) and reducing power NADPH (anti-oxidation and reductive biosynthesis)

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Oxidation and/or misfolding of SOD1 results in a deterioration in the regulation of the above processes, mitochondrial dysfunction and increase in the production of superoxides (Israelson et al., 2010

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