perianal melanotic macule macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Anorectal Melanoma: A Rare Cause

Liu, B., Chen, Y

2002 Jul 1;22(7):1175-80

The expression of core circadian regulators Bmal1 and Clock is downregulated in aging thyroid follicular epithelial cells, suggesting a decline in circadian regulatory capacity, contributing to age-related circadian disruptions (60)

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