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Intrinsic factor, Medline Plus, Vitamin B12, Fact Sheet for Consumers, National Institutes of Health, Office of Dietary Supplements, Vitamin B12, Fact Sheet for Health Professionals, National Institutes of Health, Office of Dietary Supplements Pawlak R

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Since the liver is the major site of IGF-1 production, when steatosis develops lowering insulin sensitivity, the severity of steatosis at different stages of insulin resistance and metabolic syndrome seems to be correlated with worsened circulating IGF-1 levels [234]