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They exhibited fewer side effects or improved pharmacokinetic profiles, establishing them as first-line drugs for AD

In parallel, IRF3, activates the Receptor-Interacting Protein Kinase 1 (RIPK1)-IFN activator (RIPA) pathway to induce mitochondrial apoptosis, though temporally suppressed by X-Linked Inhibitor of Apoptosis Protein (XIAP) to prevent premature cell death (62)

Additionally, the mitigating effect of AMF was associated with the upregulation of genes involved in P transport ( PHO1-2 and PHT1-7 ), the AsA-GSH pathway ( GST-2 and APX-2 ), and Al stress ( ALMT1 ) in white clover roots compared to control plants