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Larger peptides and those without specific transport mechanisms may have limited BBB penetration, which is why administration route matters so much for neurological applications

[] It is also essential to rule out the endogenous causes, which include Pseudomonas aeruginosa infection, obstructive jaundice, [] Hartn-up disease, blue diaper syndrome, [] INDIC anemia, biliverdin uria [] and to discriminate these disorders from the benign green urine discoloration

The Shank3-mutant mouse model is one of the most commonly used models to study epigenetic enzymes, and it was found that using histone methyltransferase inhibitors and histone acetylase inhibitors alone 520,521,522 or in combination 523 can both significantly improve NMDA dysfunction and social interactions in Shank3-mutant mice