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The BBB, comprising several distinct cell types, such as brain capillary endothelial cells (BCECs), astrocytes, pericytes, and nerve cells, is a complex obstacle for drug delivery in the treatment of nervous system diseases

The IC 50 value of the dual-targeted Por-nMOFs was as low as 0.74 M, which is four times lower than that of the non-targeted control group (Figure 2C)