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Its deficiency results in reduced NAD + synthesis and accumulation of its substrate, NAM, leading to increased NNMT activity and further decline in NAD + levels

One report of a randomized controlled trial that allocated supplementation with vitamin D to infertile women with PCOS found that supplementation markedly reduced high-sensitivity C-reactive protein (hs-CRP) levels and increased total antioxidant capacity, indicating the potential of vitamin D to mitigate inflammation and oxidative stress in PCOS ( These findings also laid emphasis on how vitamin D influences multiple molecular aspects involved with the pathogenesis of PCOS

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J., Lewis, R