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As the direct reaction species to react with Si-based agent is hydroxide ions, the higher the pH of the reaction solution, the greater the amount of hydrogen generated from Si-based agent

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This pace was enabled by several factors: the strength and consistency of the Phase 2 efficacy signals, Eli Lilly's extensive infrastructure for metabolic disease trials built through the tirzepatide program, the availability of well-characterized biomarkers and endpoints for obesity and diabetes, and the increasing regulatory receptivity to obesity treatments as the field matured

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