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Brenner's team discovered that the antioxidant GSH produced by T cells serves not only as a garbage collector to dispose of reactive oxygen species (ROS) and free radicals, but also as a key switch for energy metabolism that controls the immune response, and is thus of high relevance to various diseases

doi:10.1016/j.addr.2015.04.009

The mouse was generated by CRISPRCas9 technology to remove exons 24, resulting in frameshift and protein reading frame premature termination, the genotyping primers are: forward primer, 5-TGCTGCCGTCATTTTCTGCCTCAT-3

It is well known that if a residue in a second nucleic acid region that is antiparallel to a first region is thymine or uracil, then an adenine residue of the first nucleic acid region is capable of forming a specific hydrogen bond ("base pairing") with said residue in the second nucleic acid region