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ROZPUSZCZALNIK 2

While no clinical trial has tested this combination, the anti-apoptotic and antioxidant effects of HIF-PHIs provide a strong mechanistic rationale for synergistic use with agents targeting erythrocyte apoptosis pathways (e.g., Bcl-xL upregulation or NIX inhibition)

64 A large double-blind, randomized, placebo-controlled trial in detoxified patients with AUD from 11 sites in 4 European countries was performed (randomized to 6 months of treatment with SMO at 3.33.9 g/d vs placebo, followed by a 6-month medication-free period) showed efficacy in cumulative abstinence duration during the 6-month treatment period with a sustained effect during the 6-month medication-free period

Model for bacterial culture growth rate throughout the entire biokinetic temperature range