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doi: 10.1016/j.pnpbp.2017.11.020 143 VandewalleJLuypaertADe BosscherKLibertC

Nature 543 , 252256 (2017)

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Despite this, repeated clinical trials of IGF1R inhibitors, both monoclonal antibodies and small-molecule tyrosine kinase inhibitors, have failed to show clinical efficacy, either alone or in combinations, against several cancer types [20, 21]