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After 2 hours, all rats presented mild reactive changes to the surface epithelium, scarce, unevenly distributed accumulations of polymorphonuclear inflammatory cells on the surface of muscle while the controls exhibited more pronounced edema of stroma and striated muscle than BPC 157-rats ( Figs

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Although cuprizone by itself does not induce astroglial, endothelial, or microglial expression of any of the tested pro-inflammatory mediators in vitro, it mildly affects metabolic activity in endothelial cells (this study) in addition to mature oligodendrocytes [10]